AMD Prognosis

Macula Risk PGx

AMD is a multifactorial disease involving the interplay of genetic, lifestyle and environmental factors. Macula Risk PGx combines a patient's current AMD status, genetic predisposition, and non-genetic risk factors to determine his or her 2, 5 and 10-year risk of developing advanced AMD, either geographic atrophy (GA) or choroidal neovascularization (CNV). The complexity underlying AMD onset and progression is reflected in the number and diversity of risk variables incorporated into the Macula Risk PGx test as shown below:



Test Components

Clinical Exam




Risk Factors

  • AMD Status
  • 15 Genetic Markers Across 12 AMD-
    Associated Genes
  • Age
  • BMI
  • Smoking History
  • Education



Macula Risk PGx has been validated in two large, independent populations where it was shown to have a 10-year predictive accuracy of 89.5%, with a sensitivity and specificity both > 80% [6, 7].

Macula Risk PGx is most appropriate for patients with a diagnosis of Dry AMD in at least one eye. It is only available through an eye care provider and uses a simple cheek swab to take a sample of a patient's DNA. The test is covered by most insurance providers for patients with a diagnosis of AMD.